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Contributions à la recherche en néphrologie et en santé rénale

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La néphrologie et la santé rénale occupent une place centrale dans les enjeux de santé publique en Afrique et à travers le monde. Cette compilation de travaux scientifiques met en lumière des avancées significatives dans la détection, la prise en charge et la prévention des maladies rénales, en particulier dans les contextes à faibles ressources. À travers des études épidémiologiques, cliniques et thérapeutiques, ces recherches apportent un éclairage sur des thématiques essentielles telles que l’insuffisance rénale chronique, les complications rénales du COVID-19, les disparités dans l’accès aux soins néphrologiques et les défis liés à la transplantation rénale. En mettant en exergue les réalités spécifiques aux populations africaines et aux pays en développement, ces travaux offrent une base scientifique solide pour l’amélioration des politiques de santé et l’optimisation des stratégies thérapeutiques adaptées aux besoins des patients.

 

  • Prevalence and associated factors of glomerular hyperfiltration among adult stable sickle cells in Kinshasa, DR Congo. Renal failure.2024,46(2) https://pubmed.ncbi.nlm.nih.gov/39329176/ 
  • A global snapshot on health systems capacity for detection, monitoring, and management of acute kidney injury: A multinational study from the ISN-GKHA.  In press (Plos GlobalHealth)https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0003823 
  • Capacity for the management of kidney failure in the International Society of Nephrology Africa region: Report from the 2023 ISN Global Kidney Atlas (ISN-GKHA). Kidney Int Suppl 2024;13(1):12-28. https://pmc.ncbi.nlm.nih.gov/articles/PMC11010621/ 
  •  Kidney damage associated with COVID-19: from the acute to the chronic phase. Renal Failure. https://doi.org/10.1080/0886022x.2024.2316885 
  • 25[OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets. Int J Nephrology and Renovascular Disease 2024;17:71-79. https://pubmed.ncbi.nlm.nih.gov/38405026/ 
  • Factors associated with acute kidney injury (AKI) and mortality in COVID-19 patients in a Sub-Saharan African intensive care unit : a single-center prospective study. Ren Fail. 2023;45(2):2263583. doi: 10.1080/0886022X.2023.2263583. Epub 2023 Oct 23. PMID: 37870858. https://pubmed.ncbi.nlm.nih.gov/37870858/ 
  • Twitter as Educational Tool: A Global Web-Based Cross-Sectional Study on Social Media Behavior of Nephrologists. Kidney International Reports, Volume 8, Issue 11, 2469 – 2473. https://pubmed.ncbi.nlm.nih.gov/38025224/ 
  • COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings. Semin Nephrol. 2022 Sep;42(5):151318. doi: 10.1016/j.semnephrol.2023.151318. Epub 2023 Jan 16. PMID: 36796149; PMCID: PMC9841086. https://pmc.ncbi.nlm.nih.gov/articles/PMC9841086/ 
  • Access to Nephrology Care for Pregnancy-Related Acute Kidney Injury in Low- and Lower-Middle-Income Countries: A Perspective. Kidney Med. 2023 Jul 1;5(9):100695. doi: 10.1016/j.xkme.2023.100695. PMID: 37602143; https://pubmed.ncbi.nlm.nih.gov/37602143/ 
  • SARS-CoV2 infection in symptomatic patients: interest of serological tests and predictors of mortality: experience of DR Congo. BMC Infect Dis. 2022 Jan 4;22(1):21. doi: 10.1186/s12879-021-07003-9. PMID: 34983411; PMCID: PMC8724652. https://pubmed.ncbi.nlm.nih.gov/34983411/ 
  • A roadmap for kidney care in Africa: An Anlysis of international Society of Nephrology-Global Kidney Health Atlas Africa data describing current gaps and opportunities. AJN 2022;25:82-98. https://www.journals.ac.za/ajn/article/view/5100 
  • « SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject », Interdisciplinary Perspectives on Infectious Diseases, vol. 2022, Article ID 7856659, 10 pages, 2022. https://doi.org/10.1155/2022/7856659  
  • Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients. Rambam Maimonides Med J. 2021 Jul 20;12(3):e0020. doi: 10.5041/RMMJ.10443. PMID: 34270402; PMCID: PMC8284989. https://pubmed.ncbi.nlm.nih.gov/34270402/ 
  • Twitter as educational tool in nephrology: a global web based cross-sectional study on social media behaviour of nephrologists. Kidney International Reports (2022) 7, S1–S436. https://pubmed.ncbi.nlm.nih.gov/38025224/ 
  • Ineffectiveness of Intermittent hemodialysis in criticaly ill COVID-19 patient: A case of persistent heparin-induced hyperkalemia. Case report in Nephrology 2022.  https://doi.org/10.1155/2022/8613656). 
  • Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients. Rambam Maimonides medical journal, 12(3), e0020. https://doi.org/10.5041/RMMJ.10443 
  • Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross-sectional study. BMC Nephrol 21, 460 (2020). https://doi.org/10.1186/s12882-020-02131-x 
  • Prognostic Significance of Abnormal Ankle-Brachial Index Among Long-term Hemodialysis Patients in Kinshasa, the Democratic Republic of the Congo. Rambam Maimonides Med J. 2021;12(1):e0001. doi: 10.5041/RMMJ.10427. PMID: 33478626; PMCID: PMC7835119. https://pubmed.ncbi.nlm.nih.gov/33478626/ 
  • Prevalence, Location and Determinants of Valvular Calcifications in Congolese Patients on Chronic Hemodialysis: a multicenter cross sectional study. SJKDT 2020;31(5):927-936. https://pubmed.ncbi.nlm.nih.gov/33229757/ 
  • Sustained low-efficiency dialysis with regional citrate anticoagulation for liver failure patients in intensive care unit: a single center experience. Therapeutic and Apheresis 2020. https://pubmed.ncbi.nlm.nih.gov/32511862/  
  • Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study. World Journal of Cardiovascular Diseases 2018, 8, 217-228. https://pubmed.ncbi.nlm.nih.gov/32127861/ 
  • Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia. BMC Nephrol 2016; 17:178. https://www.intechopen.com/chapters/61203 
  • Acute Kidney Injury is a powerful independent predictor of mortality in critically ill patients: a multicenter prospective cohort study from Kinshasa, the Democratic Republic of Congo. BMC Nephrology 2016; 17:118. https://pubmed.ncbi.nlm.nih.gov/27557748/ 
  • Living kidney donation at Kinshasa, Democratic Republic of the Congo (DRC): Donor’s Profile, awareness and Motivations. Nephrol Dial Transplant 2015; 30 (supplement)3: iii636-iii637. https://www.researchgate.net/publication/313293533_SP782LIVING_KIDNEY_DONATION_AT_KINSHASA_DEMOCRATIC_REPUBLIC_OF_THE_CONGO_DRC_DONOR’S_PROFILE_AWARENESS_AND_MOTIVATIONS 
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  • Profil clinico-biomorphologique et évolutif de l’Insuffisance rénale aigue aux Cliniques Universitaires. Ann Afr Med 2007 ; 1 :11-19. https://anafrimed.net/profil-clinico-bio-morphologique-et-evolutif-de-linsuffisance-renale-algue-aux-cliniques-universitaires-de-kinshasa/
  • Screening for proteinuria and chronic kidney disease risk factors in Kinshasa: A World Kidney Day 2007 Study. Nephron Clin Pract 2008; 110: 220-228. https://espkinshasa.net/screening-for-proteinuria-and-chronic-kidney-disease-risk-factors-in-kinshasa-a-world-kidney-day-2007-study/
  • Lipid and non-lipid cadiovascular risk factors among black patients with idiopathic nephrotic syndrome. Ann Afr Med 2008; 1 (2):12-17. https://search.bvsalud.org/aimafro/resource/fr/biblio-1259054
  • Facteurs pronostiques de l’insuffisance rénale aiguë à Kinshasa. Ann Afr Med 2008 ; 1 (2) : 34-40. https://anafrimed.net/facteurs-pronostiques-de-linsuffisance-renale-aigue-aux-cliniques-universitaires-de-kinshasa/
  • Les facteurs de progression de l’insuffisance rénale chronique : physiopathologie et prise en charge. Ann Afr Med 2008 ; 1 (2) : 80-87. https://anafrimed.net/les-facteurs-de-progression-de-linsuffisance-renale-chronique-physiopathologie-et-prise-en-charge/
  • Infection à virus de l’hépatite C révélée par l’association Syndrome néphrotique à Glomérulonéphrite Membranoproliférative – Amyloïdose systémique. Ann Afr Med 2009 ; 3 (1): 382-387. https://anafrimed.net/infection-a-virus-de-lhepatite-c-revelee-par-lassociation-syndrome-nephrotique-a-glomerulonephrite-membranoproliferative-amyloidose-systemique-a-propos-dune-observation/
  • Statut socio-économique et protéinurie: résultats de la campagne de dépistage des maladies de rein de 2007 à Kinshasa. Ann Afr Med 2009 ; 2 (3): 1-9. https://anafrimed.net/statut-socio-economique-et-proteinurie-resultats-de-campagne-de-depistage-des-maladies-de-rein-2007-a-kinshasa/
  • Prevalence and determinants of microalbuminuria and macroalbuminuria in children and young adults with type 1 diabetes in Kinshasa. Neph ther 2010; 6(10): 40-6. https://pubmed.ncbi.nlm.nih.gov/19853548/
  • Albuminurie pathologique lors du dépistage du diabète en milieu semi-rural (cité de Kisantu en RDCongo). Neph ther 2010 ; 6 : 513-519. https://www.sciencedirect.com/science/article/abs/pii/S1769725510000854
  • Prevalence of low estimated glomerular filtration rate, proteinuria and associated risk factors among HIV-infected black patients using cockroft-gault and modification of diet in renal disease study equations. JAIDS 2012; 59: 59-64. https://pubmed.ncbi.nlm.nih.gov/21926635/
  • Chronic kidney disease among high school students of Kinshasa. BMC Nephrol 2012; 13: 24. https://espkinshasa.net/chronic-kidney-disease-among-high-school-students-of-kinshasa/
  • Prévalence de la protéinurie et son association avec le VIH/Sida chez l’enfant Congolais à Kinshasa, en République Démocratique du Congo. Nephrol Ther 2012 ; 8 : 163-167. https://www.em-consulte.com/article/717656/prevalence-de-la-proteinurie-et-son-association-av
  • Sclérodermie systémique associée à une glomérulonéphrite primitive. A propos d’un cas. Ann Afr Med 2013 ; 6 (4) : 1525-1529. https://anafrimed.net/sclerodermie-systemique-associee-a-une-glomerulonephrite-extra-membraneuse-primitive-a-propos-dun-cas-systemic-sclerosis-and-primary-membranous-glomerulonephritis-a-case-report/
  • Prevalence of microalbuminuria and diagnostic value of dipstick proteinuria in outpatients from HIV clinics in Bukavu, the Democratic Republic of Congo. BMC Nephrol 2014, 15:146. https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-146
  • Association between Risk factors and abnormal albuminuria in a Congolese patients with type 2 diabetes treated at tertiary center. Diab Res Clin Pract 2014; 103 S: S1-S61. OP 49. https://www.academia.edu/110011667/OP49_Association_between_risk_factors_and_abnormal_albuminuria_in_Congolese_patients_with_type_2_diabetes_treated_at_a_tertiary_center?uc-sb-sw=34149691
  • Sickle cell trait is not associated with chronic kidney disease in adult Congolese patients:a clinic-based, cross sectional study, CVJA 2015, 26 (3). https://pubmed.ncbi.nlm.nih.gov/26592908/
  • Left Ventricular Structure, Geometry and Systolic Function among Hypertensive Black Patients with Reduced Kidney Function. WJCD 2015; 5: 287-295. https://www.scirp.org/journal/paperinformation?paperid=60405
  • Microalbuminuria among HIV-infected antiretroviral therapy-naïve children in Democratic Republic of Congo. Pediatr Nephrololy 2015; 31(5): 769-72. https://pubmed.ncbi.nlm.nih.gov/26628284/

  • The atherogenic dyslipidemia ratio log (TG)/HDL-c was not associated with urinary albumin excretion rate (UAER) and increased cardiovascular risk in black patients with type 2 diabetes. WJCD 2016; 6 (1). https://www.scirp.org/journal/paperinformation?paperid=63054
  • . Diurèse résiduelle à l’initiation de l’hémodialyse et profil clinico-biologique des patients insuffisants rénaux en milieu hospitalier de Kinshasa, République Démocratique du Congo. Ann Afr med 2016 ; 9 (4). https://anafrimed.net/diurese-residuelle-a-linitiation-de-lhemodialyse-profil-clinico-biologique-patients-insuffisants-renaux-milieu-hospitalier-de-kinshasa-republique-democratique-congo/
  • Obesity Associated and Renal Prognosis (Assessed by eGFR and Albuminuria) in Type 2 Diabetics in International Journal of Diabetology & Vascular Disease Research (IJDVR) 2016; 4(1): 140-145. https://soconeph.org/obesity-and-renal-prognosis-assessed-by-albuminuria-and-egfr-in-type-2-diabetics-in-kinshasa/

  • Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia. BMC Nephrol 2016 ; 17:178. https://pubmed.ncbi.nlm.nih.gov/27855647/
  • Acute kidney injury is a powerful independent predictor of mortality in critically ill patients: a multicenter prospective cohort study from Kinshasa, the Democratic Republic of Congo.  BMC Nephrol 2016; 17:118. https://pubmed.ncbi.nlm.nih.gov/27557748/
  • Sickle Cell Trait, Hemoglobin Levels and Anemia among Black Patients with Predialysis Chronic Kidney Disease: A Post Hoc Analysis. WJCD 2016; 6: 258-264. https://www.scirp.org/journal/paperinformation?paperid=69637
  • Prevalence and risk factors of pre-hypertension in Congolese pre and post-menopausal women. Afr Health Sci 2016; 16(4): 979-985. https://pubmed.ncbi.nlm.nih.gov/28479890/
  • Impact of residual urine volume decline on the survival of chronic hemodialysis patients in Kinshasa. BMC Nephrol 2016; 17:182. DOI 10.1186/s12882-016-0401-9. https://pubmed.ncbi.nlm.nih.gov/27871253/
  • Congolese children with sickle cell trait may exhibit glomerular hyperfiltration: A case control study. J Clin Lab Anal 2017 Jan 19. doi: 10.1002/jcla.22143. https://pmc.ncbi.nlm.nih.gov/articles/PMC6817090/
  • Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia. Acta Paediatr 2017; 106(5): 819-824. https://pubmed.ncbi.nlm.nih.gov/28218952/
  • Comparison of the Performance of Three Commonly Used Electrocardiographic Indexes for the Diagnosis of Left Ventricular Hypertrophy in Black Hypertensive Patients with Reduced Kidney Function Managed at a Tertiary Healthcare Hospital: A Post-Hoc Analysis. WJCD 2017 ; 7 : 105-118. https://www.scirp.org/reference/referencespapers?referenceid=1588539
  • Avant-projet de loi sur la transplantation et le prélevement d’organes, tissus et cellules. Ann Afr Med 2017 ; 11 : e2697. https://www.ajol.info/index.php/aamed/article/view/214123
  • Reverse epidemiology of elevated blood pressure among chronic hemodialysis black patients with stroke: a historical cohort study. BMC Nephrol 2017; 18: 277. DOI 10.1186/s12882-017-0697-0. https://pubmed.ncbi.nlm.nih.gov/28854899/
  • Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state: a first report from Central Africa. Clin Kidney J 2017; 10(4): 479-86. https://pubmed.ncbi.nlm.nih.gov/28852485/
  • Trends in the prevalence of chronic kidney disease and its risk factors in Kinshasa over 10 years. afranjournal.org/index.php/ajn/article/viewFile/2549/1616 Volume 20, No 1, 2017. https://pubmed.ncbi.nlm.nih.gov/19622160/
  • Blood pressure patterns and factors associated with relative hypertension among steady state sickle cell disease patients in Kinshasa, Democratic Republic of the Congo. A cross-sectional study. WJCD 2018; 8: 217-22 https://www.scirp.org/reference/referencespapers?referenceid=2241284
  • analyse de survie et des facteurs associés à la perte de la fonction rénale du greffon. Ann Afr Med 2017;11(1) : e2698. https://www.researchgate.net/publication/335687867_04-Suivi-post-greffe-renale-a-Kinshasa-analyse-de-survie-et-des-facteurs-associes-a-la-perte-de-la-fonction-renale-du-greffon_4
  • Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease, in Kinshasa. BMC Nephrol 2018; 19(1):68. https://pubmed.ncbi.nlm.nih.gov/29554877/
  • Magnitude of Elevated iron stores and Risk associated in Steady state Sickle Cell Anemia Congolese children: a cross sectional study. BMC Hematology 2019; 19: 3. https://pubmed.ncbi.nlm.nih.gov/30774961/
  • G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa. Clinical Kidney Journal 2019; 12 (2): 188-195. https://pmc.ncbi.nlm.nih.gov/articles/PMC6452203/
  • Response to single dose hepatitis B vaccine in Congolese non-HIV hemodialysis patients: a prospective observational study. The Pan African Medical Journal 2019; 34:122. doi:10.11604/pamj.2019.34.122.19603. https://www.ajol.info/index.php/pamj/article/view/210635
  • Impact of Hypertension on the Survival of chronic hemodialysis patients in Kinshasa: A Historical Cohort Study. Ann Afr Med 2019; 12 (3): e3302-e3312. https://www.ajol.info/index.php/aamed/article/view/210713
  • Interdialytic 24-Hours Ambulatory Blood Pressure versus Dialysis Unit Blood Pressure for the Diagnosis of Electrocardiographic-Left Ventricular Hypertrophy in Chronic Hemodialysis Black Patients. World Journal of Cardiovascular Diseases, 2019; 9: 846-856 https://www.scirp.org/journal/paperinformation?paperid=96619
  • Determinants of Intrarenal Vascular Resistance in Congolese Sickle Cell Patients in Kinshasa: A Hospital-Based Study. International Journal of Health Sciences and Research 2020; 10(7): 95-102. https://www.ijhsr.org/IJHSR_Vol.10_Issue.7_July2020/16.pdf
  • Recommandations de la Société Congolaise de Néphrologie (SOCONEPH) pour la Prise en Charge des Patients en Dialyse dans le contexte de Pandémie à COVID-19. Ann Afr Med 2020; 13 (3) : 3727-3730. https://search.bvsalud.org/aimafro/?lang=fr&q=au:%22Mayamba%20Nlandu,%20Yannick%22
  • First case of Covid-19-Associated Collapsing Glomerulopathy in Sub-Saharan Africa. Case Reports in Nephrology 2020. ID 8820713. https://doi.org/10.1155/2020/8820713.
  • Knowledge and Skill Assessment of Congolese Traditional Healers on Healthy and Diseased Kidney. ECCMC 2020; 3 (10): 9-18. https://www.researchgate.net/publication/344440988_Knowledge_and_Skill_Assessment_of_Congolese_Traditional_Healers_on_Healthy_and_Diseased_Kidney
  • Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross sectional study. BMC Nephrol 2020; 21: 460. https://pubmed.ncbi.nlm.nih.gov/33148221/
  • Assessing the Potential and Necessity for Kidney Transplantation in the Democratic Republic of the Congo. Transplantation 2021; 105 (4): 677-678. https://pubmed.ncbi.nlm.nih.gov/33760785/
  • Intradialytic Hypotension during Dialysis for Acute Kidney Injury in Congolese Patients: Prevalence, Risk factors and Outcome ». Ann Afr Med 2021: 14 (4): e4319-e4327. https://www.ajol.info/index.php/aamed/article/view/215727/203441
  • Hepatitis C Virus Infection and Genotypes in Chronic Hemodialysis Patients in Kinshasa:Prevalence and Risk Factors. Ann Afr Med 2022. https://www.ajol.info/index.php/aamed/article/view/224608