Contributions à la recherche en néphrologie et en santé rénale

La néphrologie et la santé rénale occupent une place centrale dans les enjeux de santé publique en Afrique et à travers le monde. Cette compilation de travaux scientifiques met en lumière des avancées significatives dans la détection, la prise en charge et la prévention des maladies rénales, en particulier dans les contextes à faibles ressources. À travers des études épidémiologiques, cliniques et thérapeutiques, ces recherches apportent un éclairage sur des thématiques essentielles telles que l’insuffisance rénale chronique, les complications rénales du COVID-19, les disparités dans l’accès aux soins néphrologiques et les défis liés à la transplantation rénale. En mettant en exergue les réalités spécifiques aux populations africaines et aux pays en développement, ces travaux offrent une base scientifique solide pour l’amélioration des politiques de santé et l’optimisation des stratégies thérapeutiques adaptées aux besoins des patients.

 

• Prevalence and associated factors of glomerular hyperfiltration among adult stable sickle cells in Kinshasa, DR Congo. Renal failure.2024,46(2) https://pubmed.ncbi.nlm.nih.gov/39329176/ 

• A global snapshot on health systems capacity for detection, monitoring, and management of acute kidney injury: A multinational study from the ISN-GKHA.  In press (Plos GlobalHealth)https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0003823 

• Capacity for the management of kidney failure in the International Society of Nephrology Africa region: Report from the 2023 ISN Global Kidney Atlas (ISN-GKHA). Kidney Int Suppl 2024;13(1):12-28. https://pmc.ncbi.nlm.nih.gov/articles/PMC11010621/ 

•  Kidney damage associated with COVID-19: from the acute to the chronic phase. Renal Failure. https://doi.org/10.1080/0886022x.2024.2316885 

• 25[OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets. Int J Nephrology and Renovascular Disease 2024;17:71-79. https://pubmed.ncbi.nlm.nih.gov/38405026/ 

• Factors associated with acute kidney injury (AKI) and mortality in COVID-19 patients in a Sub-Saharan African intensive care unit : a single-center prospective study. Ren Fail. 2023;45(2):2263583. doi: 10.1080/0886022X.2023.2263583. Epub 2023 Oct 23. PMID: 37870858. https://pubmed.ncbi.nlm.nih.gov/37870858/ 

• Twitter as Educational Tool: A Global Web-Based Cross-Sectional Study on Social Media Behavior of Nephrologists. Kidney International Reports, Volume 8, Issue 11, 2469 – 2473. https://pubmed.ncbi.nlm.nih.gov/38025224/ 

• COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings. Semin Nephrol. 2022 Sep;42(5):151318. doi: 10.1016/j.semnephrol.2023.151318. Epub 2023 Jan 16. PMID: 36796149; PMCID: PMC9841086. https://pmc.ncbi.nlm.nih.gov/articles/PMC9841086/ 

• Access to Nephrology Care for Pregnancy-Related Acute Kidney Injury in Low- and Lower-Middle-Income Countries: A Perspective. Kidney Med. 2023 Jul 1;5(9):100695. doi: 10.1016/j.xkme.2023.100695. PMID: 37602143; https://pubmed.ncbi.nlm.nih.gov/37602143/ 

• Predictors of poor prognosis requiring intubation in COVID-19 patients admitted in Intensive Care Unit: a Congolese observational study https://dx.doi.org/10.4314/aamed.v16i4.2. https://www.ajol.info/index.php/aamed/article/view/256043 

• SARS-CoV2 infection in symptomatic patients: interest of serological tests and predictors of mortality: experience of DR Congo. BMC Infect Dis. 2022 Jan 4;22(1):21. doi: 10.1186/s12879-021-07003-9. PMID: 34983411; PMCID: PMC8724652. https://pubmed.ncbi.nlm.nih.gov/34983411/ 

• Kidney Health for All – Bridging the gap to better kidney care in Africa ». AJN 2022;25:108-115. https://www.journals.ac.za/ajn/article/view/5051 

• A roadmap for kidney care in Africa: An Anlysis of international Society of Nephrology-Global Kidney Health Atlas Africa data describing current gaps and opportunities. AJN 2022;25:82-98. https://www.journals.ac.za/ajn/article/view/5100 

• « SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject », Interdisciplinary Perspectives on Infectious Diseases, vol. 2022, Article ID 7856659, 10 pages, 2022. https://doi.org/10.1155/2022/7856659  

• Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients. Rambam Maimonides Med J. 2021 Jul 20;12(3):e0020. doi: 10.5041/RMMJ.10443. PMID: 34270402; PMCID: PMC8284989. https://pubmed.ncbi.nlm.nih.gov/34270402/ 

• Prevalence and factors associated with rhabdomyolysis in covid-19 patients: an observational study. Kidney International Reports (2022) 7, S1–S436. https://pmc.ncbi.nlm.nih.gov/articles/PMC8854896/ 

• Twitter as educational tool in nephrology: a global web based cross-sectional study on social media behaviour of nephrologists. Kidney International Reports (2022) 7, S1–S436. https://pubmed.ncbi.nlm.nih.gov/38025224/ 

• Ineffectiveness of Intermittent hemodialysis in criticaly ill COVID-19 patient: A case of persistent heparin-induced hyperkalemia. Case report in Nephrology 2022.  https://doi.org/10.1155/2022/8613656). 

• SARS-CoV2 infection in symptomatic patients: interest of serological tests and predictors of mortality: experience of DR Congo. BMC Infect Dis 22, 21 (2022). https://doi.org/10.1186/s12879-021-07003-9 

• Hepatitis C Virus Infection and Genotypes in Chronic Hemodialysis Patients in Kinshasa: Prevalence and Risk Factors. Ann Afr Med 2022. https://www.ajol.info/index.php/aamed/article/view/224608 

• Predictors of mortality in COVID-19 patients at Kinshasa Medical Center and a survival analysis: a retrospective cohort study. BMC Infect Dis 21, 1272 (2021). https://doi.org/10.1186/s12879-021-06984-x 

• Frequency and factors associated with proteinuria in COVID-19 patients: A cross-sectional study. Pan Afr Med Journal 2021. https://www.panafrican-med-journal.com/content/article/40/37/full/ 

• ntradialytic Hypotension during Dialysis for Acute Kidney Injury in Congolese Patients: Prevalence, Risk factors and Outcome ». Ann Afr Med 2021: 14 (4): e4319-e4327. https://www.ajol.info/index.php/aamed/article/view/215727 

• Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients. Rambam Maimonides medical journal, 12(3), e0020. https://doi.org/10.5041/RMMJ.10443 

• Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross-sectional study. BMC Nephrol 21, 460 (2020). https://doi.org/10.1186/s12882-020-02131-x 

• Prognostic Significance of Abnormal Ankle-Brachial Index Among Long-term Hemodialysis Patients in Kinshasa, the Democratic Republic of the Congo. Rambam Maimonides Med J. 2021;12(1):e0001. doi: 10.5041/RMMJ.10427. PMID: 33478626; PMCID: PMC7835119. https://pubmed.ncbi.nlm.nih.gov/33478626/ 

• Disparities in Access to Kidney Transplantation in Developing Countries. Transplantation. 2021;105(11):2325-2329. https://pubmed.ncbi.nlm.nih.gov/34709218/ 

• Assessing the Potential and Necessity for Kidney Transplantation in the Democratic Republic of the Congo. Transplantation. 2021;105(4):677-678. https://pubmed.ncbi.nlm.nih.gov/33760785/ 

• First Case of Covid-19 Associated Collapsing Glomerulopathy from Sub-saharan Africa. Case reports in nephrology, 2020, 8820713. https://doi.org/10.1155/2020/8820713 

• Survie des patients et Prédicteurs de décès dans un Service de Réanimation polyvalente d’Afrique sub-Saharienne : Etude prospective observationnelle. (In Press). https://pubmed.ncbi.nlm.nih.gov/33760785/ 

• Prevalence, Location and Determinants of Valvular Calcifications in Congolese Patients on Chronic Hemodialysis: a multicenter cross sectional study. SJKDT 2020;31(5):927-936. https://pubmed.ncbi.nlm.nih.gov/33229757/ 

• COVID-19: An ISN Fellow Congolese Experience. Dispatches from the Frontlines [Internet]. https://www.afro.who.int/news/frontlines-congos-covid-19-battle 

• Lenteur de propagation du COVID-19 en Afrique Subsaharienne : Réalité ou sommet de l’Iceberg ? Cas de la République Démocratique du Congo. Ann Afr Med 2020 ;13(3) : e3759-e3764.  https://anafrimed.net/lenteur-de-propagation-de-la-covid-19-en-afrique-subsaharienne-realite-ou-sommet-de-liceberg-cas-de-la-republique-democratique-du-congo/ 

• Infection à Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) : bases moléculaires du traitement antiviral ciblant le cycle de vie du virus. Ann Afr Med 2020 ;13(3) : e3702-e3712. https://anafrimed.net/infection-a-severe-acute-respiratory-syndrome-coranovirus-2-sars-cov-2-bases-biomoleculaires-du-traitement-antiviral-ciblant-le-cycle-de-vie-du-virus-sars-cov-2-life-cycle-and-bi/ 

• Recommandation pour le prise en charge des patients en dialyse dans le contexte de pandémie à COVID-19. Ann Afr Med 2020;13(3):e3727-e3729. https://www.ajol.info/index.php/aamed/article/view/210317 

• Sustained low-efficiency dialysis with regional citrate anticoagulation for liver failure patients in intensive care unit: a single center experience. Therapeutic and Apheresis 2020. https://pubmed.ncbi.nlm.nih.gov/32511862/  

• Disparities In Transplantation Access Across different Countries: An ISN Fellows Collaborative Study. Kidney Int Report 2020;5:S139-140. https://www.theisn.org/blog/2020/09/02/isn-fellows-collaborate-on-research-project-exploring-transplantation-access-patterns/ 

• Cost Estimated of Chronic Haemodialysis in Kinshasa:  A Prospective Bicentric Study. Hemodial Int 2020;24(1):121-128. https://pubmed.ncbi.nlm.nih.gov/31750998/ 

• Insuffisance rénale terminale au Maghreb et en Afrique : Panorama des programmes de transplantation rénale au Maghreb et en Afrique. Néphrol Ther 2020;16(3) :171-176. https://stm.cairn.info/revue-nephrologie-et-therapeutique-2020-3-page-171?lang=fr 

• Cabazitaxel-induced Thrombotic Microangiopathy. Case Reports in Nephrology, vol. 2019, Article ID 8591283. https://pmc.ncbi.nlm.nih.gov/articles/PMC6885798/ 

• Hepatitis B vaccine response in hemodialysis patients: evaluation of Kinshasa vaccination Protocol. The Pan African Medical Journal 2019; 34:122. https://pmc.ncbi.nlm.nih.gov/articles/PMC7906547/ 

• Aki Practice Patterns : A multinational Survey. KI Reports 2019 ;4 :S74-75. https://pmc.ncbi.nlm.nih.gov/articles/PMC10821757/ 

• Impact of Hypertension on the Survival of chronic hemodialysis patients in Kinshasa: A Historical Cohort Study. Ann Afr Med 2019;12(3):e3302. https://www.ajol.info/index.php/aamed/article/view/210713 

• Toxines urémiques de moyen poids moléculaire – un véritable regain d’intérêt. Néphrol Ther 2019 ;15(2) :82-90. https://stm.cairn.info/revue-nephrologie-et-therapeutique-2019-2-page-82?lang=fr 

• Performance of glomerular filtration rate estimation equations in Congolese healthy adults: inopportunity of ethnic correction. Plos One 2018. https://pubmed.ncbi.nlm.nih.gov/29499039/ 

• Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study. World Journal of Cardiovascular Diseases 2018, 8, 217-228. https://pubmed.ncbi.nlm.nih.gov/32127861/ 

• Prevalence of Circadian Blood Pressure Patterns and Factors Associated with Non-Dipping among Black Patients with Untreated and Treated Hypertension: A Cross-Sectional Study. World Journal of Cardiovascular Diseases 2018, 7, 399-412. https://www.scirp.org/journal/paperinformation?paperid=80547 

• Reverse Epidemiology of Elevated Blood Pressure Among Chronic Hemodialysis Black Patients with Stroke: a Historical Cohort Study. BMC Nephrol 2017; 18: 277. https://pubmed.ncbi.nlm.nih.gov/28854899/ 

• Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia. BMC Nephrol 2016; 17:178. https://www.intechopen.com/chapters/61203 

• Acute Kidney Injury is a powerful independent predictor of mortality in critically ill patients: a multicenter prospective cohort study from Kinshasa, the Democratic Republic of Congo. BMC Nephrology 2016; 17:118. https://pubmed.ncbi.nlm.nih.gov/27557748/ 

• Living kidney donation at Kinshasa, Democratic Republic of the Congo (DRC): Donor’s Profile, awareness and Motivations. Nephrol Dial Transplant 2015; 30 (supplement)3: iii636-iii637. https://www.researchgate.net/publication/313293533_SP782LIVING_KIDNEY_DONATION_AT_KINSHASA_DEMOCRATIC_REPUBLIC_OF_THE_CONGO_DRC_DONOR’S_PROFILE_AWARENESS_AND_MOTIVATIONS